What is estradiol?

Estradiol is responsible for the regulation of female menstrual reproductive cycles and for the development and maintenance of female secondary sex characteristics [7].

Why is it measured?

Analysis of Estradiol levels is perfect for a variety of uses in men, such as:

  1. Testosterone Conversion: Since estradiol is converted from testosterone, unusually high or low levels of estradiol can indicate a problem with testosterone levels or the conversion process.

  2. Bone Health: Just like in women, estradiol is important for bone health in men. Monitoring estradiol levels can help assess the risk of osteoporosis in men.

  3. Gynecomastia: Elevated levels of estradiol in men can lead to the development of breast tissue (gynecomastia). Measuring estradiol can help diagnose the cause of this condition.

  4. Sexual Function and Libido: Estradiol is involved in modulating libido and erectile function in men. Unusual levels can be associated with sexual dysfunctions.

In women, it is used for:

  1. Menstrual Cycle Regulation: Estradiol levels vary throughout the menstrual cycle and are a key factor in regulating it. Monitoring these levels can help in understanding if the cycle is normal.

  2. Fertility and Ovulation: In women who are trying to conceive, measuring estradiol levels can help determine whether the ovaries are producing eggs properly.

  3. Hormone Replacement Therapy (HRT): Women who are undergoing HRT, especially around the time of menopause, may have their estradiol levels monitored to ensure that they are receiving the appropriate dose of hormones.

  4. Polycystic Ovary Syndrome (PCOS): Women with PCOS may have elevated levels of estradiol. Monitoring these levels can be part of the diagnostic process.

How can I better understand my results?

Normally Menstruating Females: 

  • Early Follicular Phase: 22-115 pg/mL
  • Mid-Follicular Phase: 25-115 pg/mL
  • Mid-Luteal Phase: 37-246 pg/mL
  • Peri-Ovulatory Phase: 32-517 pg/mL

Post-Menopausal Females (not on HRT)

  • <15-25 pg/mL


  •  10 to 50 pg/mL for men.

Where can I learn more?

Read Mount Sinai’s synopsis of their estradiol tests.

For a scientific explanation of estradiol, read here.