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What is cortisol?

Cortisol is a hormone synthesized and secreted by the adrenal glands of the kidneys that plays a major role in regulating stress, metabolism, and immunity. It follows a diurnal rhythm that is affected by sleep- naturally rising in the early morning, peaking around 30 minutes after waking up, and subsequently falling in the evening.


cortisol

Why is cortisol important?

High cortisol levels are an indicator of acute (sudden), chronic (long-term), and/or traumatic (life-threatening) stress. Secondary factors associated with mental stress include alcohol drinking, smoking, a lack of exercise, inadequate sleep, and poor nutrition. Over time, prolonged high levels of cortisol (Cushing’s disease or hypercortisolism) can lead to weight gain, fat redistribution, poor sleep, a lowered immune system, and increased inflammation. Low levels might indicate poor adrenal function or Addison’s disease.

How can I better understand my fingerprick cortisol levels?

Here are some ranges to help you interpret your blood serum cortisol levels:

Lab ranges if taken in the morning:

  • Out of range: 0-6.6 ug/dL OR >19.5 ug/dL
  • In range: 6.7-9.9 ug/dL
  • Optimal: 10-15 ug/dL
  • In range: 15.1-19.4 ug/dL

SiPhox Grades:

  • Optimal: 10-15 ug/dL
  • Good: 6.7-10 OR 15-19.4 ug/dL
  • Fair: None
  • Pay attention: <6.7 OR >19.4 ug/dL

While levels in the lower range are better for inflammation, morning cortisol levels may indicate adrenal insufficiency [1]. Cortisol levels consistently above the normal range may indicate Cushing’s disease which could point towards the presence of tumors. Keep in mind that certain medications can alter cortisol production, so it is important to talk to your doctor if you are concerned with your levels.

How does a 3-Point Saliva test differ?

The three-point cortisol test involves collecting saliva at three different times of the day (morning, afternoon, and night). Although it is expected to see natural variations, atypically high or low results at these specific times may indicate an adrenal gland disorder. Because saliva is convenient to collect, the 3-point salivary cortisol test may be more beneficial for those who are looking to confirm the presence of abnormalities or underlying diseases through repeat testing throughout the day.

Ultimately, the main difference between the saliva and blood tests is that the three-point test is more diagnostic in nature, especially for conditions that affect cortisol rhythm, while the blood test is more suited for general monitoring.

How can I maintain optimal cortisol levels?

If your cortisol levels are on the higher side, studies suggest the following interventions may help with regulation:

Dietary Changes: Including herbs and natural supplements such as ashwagandha, rhodiola, lemon balm, and chamomile can help to reduce cortisol [2][3][4][5]. Foods such as dark chocolate, garlic, fermented foods (kimchi, yogurt), and plants high in vitamin C (oranges, broccoli) can help as well.

Lifestyle Changes: Aim for 8 hours of restful sleep (avoid caffeine after midday, wear blue-light blocking glasses, put the screens away before bed), and spend more time in nature to lower your cortisol levels [6][7][8][9]. Practicing yoga, tai chi, qi gong, and other mindfulness meditation exercises and surrounding yourself with healthy relationships can help as well [10][11].

If your cortisol levels are on the lower side, studies suggest the following interventions may help with regulation:

Lifestyle Changes: High-intensity exercise and consuming caffeine can help to increase cortisol levels [12][13].

Where can I learn more?

DISCLAIMER: IF YOU ARE CONCERNED WITH ANY OF YOUR RESULTS, PLEASE CONSULT WITH YOUR PHYSICIAN.

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