ApoA1

What is ApoA1?

ApoA (apolipoprotein A) is a protein carrier for HDL. ApoA is considered to be the most informative biomarker for “good" cholesterol and can be used to determine your risk for cardiovascular disease. ApoA1 in particular is the most abundant protein associated with HDL.

Note: HDL is known as "good" cholesterol because of its anti-atherogenic effects (prevents plaque from clogging arteries), but high HDL can result in negative cardiovascular outcomes, too.

Why is it included in the Cardiovascular Axis?

Both HDL cholesterol and ApoA1 are, in most clinical conditions, anti-atherogenic, so the higher the values, the lower the cardiovascular risk. Your ApoA1 measurement can be an important predictor of your cardiovascular health, and is thus included in SiPhox Health's base panel.

How can I better understand my results?

High ApoA1 may be caused by genetic disorders, certain medications, or recent weight loss. Low ApoA1 may be caused by diabetes, coronary artery disease, Tangier disease (< 25 mg/dL), liver disorders, and certain lifestyle choices such as smoking cigarettes. Because ApoA1 levels can be an indicator of many deleterious diseases, it is important to consult with your physician if you are concerned with your levels. Aim for levels to fall higher in the normal range.

Males:

Females:

To improve your apolipoprotein profile, you can try:

  • Limit foods with added sugar (sweets, jam, sugar-sweetened beverages)
  • Consume fermented dairy products (fermented milk, cheese)
  • Avoid smoking
  • Increase physical activity
  • If you are obese, consider losing weight through a healthy diet and exercise

Where can I learn more?

University of Rochester Medical Center - Apolipoprotein A

Discover Cholesterol Efflux (video) - The importance of ApoA-1 in cholesterol efflux and atherosclerosis

 

DISCLAIMER: IF YOU ARE CONCERNED WITH ANY OF YOUR RESULTS, PLEASE CONSULT WITH YOUR PHYSICIAN.