Why do I have severe abdominal pain?

Severe abdominal pain can stem from various causes including digestive issues, infections, organ problems, or serious conditions requiring immediate care. Tracking symptoms, identifying triggers, and getting appropriate testing helps determine the cause and guide treatment.

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Understanding Severe Abdominal Pain

Severe abdominal pain is one of the most common reasons people seek medical attention, affecting millions of Americans each year. The abdomen houses numerous vital organs including the stomach, intestines, liver, gallbladder, pancreas, kidneys, and reproductive organs, making it challenging to pinpoint the exact source of pain without proper evaluation.

The intensity, location, and nature of abdominal pain can vary significantly. Some people experience sharp, stabbing sensations, while others describe cramping, burning, or a constant dull ache. Understanding these characteristics, along with accompanying symptoms, helps healthcare providers narrow down potential causes and determine the appropriate course of action.

Common Causes of Severe Abdominal Pain

Digestive System Disorders

The digestive system is often the culprit behind severe abdominal pain. Gastroenteritis, commonly known as stomach flu, causes inflammation of the stomach and intestines, leading to cramping, nausea, and diarrhea. Irritable bowel syndrome (IBS) affects up to 15% of the population and can cause recurring episodes of severe cramping, bloating, and altered bowel habits.

Common Digestive Disorders and Their Characteristics

These conditions often require different diagnostic approaches and long-term management strategies.
ConditionPain LocationKey SymptomsTypical Triggers
IBSIBSLower abdomenCramping, bloating, altered bowel habitsStress, certain foods, hormones
GERDGERDUpper abdomen/chestBurning pain, acid reflux, difficulty swallowingLarge meals, lying down, acidic foods
Crohn's DiseaseCrohn's DiseaseRight lower abdomenSevere cramping, diarrhea, weight lossStress, certain foods, smoking
Ulcerative ColitisUlcerative ColitisLeft side/lowerBloody diarrhea, urgency, crampingStress, NSAIDs, certain foods

These conditions often require different diagnostic approaches and long-term management strategies.

Inflammatory bowel diseases like Crohn's disease and ulcerative colitis cause chronic inflammation of the digestive tract, resulting in severe pain, diarrhea, weight loss, and fatigue. These conditions often require ongoing monitoring of inflammatory markers and nutritional status to manage effectively.

Gallbladder and Liver Conditions

Gallstones affect approximately 10-15% of adults and can cause excruciating pain in the upper right abdomen, especially after eating fatty foods. The pain may radiate to the back or right shoulder blade. Cholecystitis, inflammation of the gallbladder, presents similarly but often includes fever and requires immediate medical attention.

Hepatitis, whether viral or caused by alcohol or medications, inflames the liver and can cause upper right abdominal pain, jaundice, and fatigue. Regular monitoring of liver function through blood tests helps track the progression and response to treatment. If you're experiencing persistent abdominal pain along with other metabolic symptoms, comprehensive testing can help identify underlying issues.

Kidney and Urinary Issues

Kidney stones cause some of the most severe pain people experience, often described as waves of excruciating pain in the back and side that radiates to the lower abdomen and groin. Urinary tract infections (UTIs) can also cause lower abdominal pain, burning during urination, and frequent urges to urinate. When UTIs spread to the kidneys, they cause more severe pain, fever, and require prompt antibiotic treatment.

Emergency Warning Signs

Certain symptoms accompanying severe abdominal pain require immediate emergency care. These red flags indicate potentially life-threatening conditions that need urgent evaluation and treatment.

  • Sudden, severe pain that comes on rapidly
  • Pain accompanied by fever above 101°F
  • Persistent vomiting, especially with blood
  • Blood in stool or urine
  • Abdominal rigidity or extreme tenderness to touch
  • Signs of shock: rapid heartbeat, dizziness, cold sweats
  • Inability to pass gas or have bowel movements
  • Severe pain during pregnancy
  • Yellowing of skin or eyes (jaundice)
  • Difficulty breathing along with abdominal pain

Appendicitis typically begins with pain around the navel that shifts to the lower right abdomen, becoming sharper and more severe over hours. Bowel obstruction causes severe cramping, bloating, and inability to pass gas or stool. A perforated ulcer causes sudden, severe pain that may temporarily improve before worsening, often accompanied by signs of shock.

Location Matters: What Different Areas of Pain Mean

Upper Abdominal Pain

Pain in the upper abdomen often relates to the stomach, esophagus, or upper digestive organs. Gastroesophageal reflux disease (GERD) causes burning pain in the upper abdomen and chest, especially after eating. Peptic ulcers create gnawing or burning pain that may improve or worsen with food. Pancreatitis causes severe upper abdominal pain that radiates to the back and worsens when lying flat.

Lower Abdominal Pain

Lower abdominal pain frequently involves the intestines, bladder, or reproductive organs. In women, ovarian cysts can cause sharp pain on one side, while endometriosis creates chronic pelvic pain that worsens during menstruation. Men may experience lower abdominal pain from hernias or testicular conditions that refer pain to the abdomen.

Diverticulitis, inflammation of small pouches in the colon, typically causes left lower abdominal pain, fever, and changes in bowel habits. This condition becomes more common with age, affecting about half of people over 60.

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Diagnostic Tests and Biomarkers

Proper diagnosis of severe abdominal pain often requires a combination of physical examination, imaging studies, and laboratory tests. Blood tests can reveal important information about inflammation, infection, and organ function that helps identify the underlying cause.

Key biomarkers for evaluating abdominal pain include C-reactive protein (CRP) and white blood cell count for inflammation and infection, liver enzymes (ALT, AST, bilirubin) for liver and gallbladder issues, and pancreatic enzymes (amylase, lipase) for pancreatitis. Kidney function tests including creatinine and BUN help identify urinary system problems. For comprehensive health monitoring that includes many of these crucial markers, regular testing provides valuable insights into your overall wellness.

Complete blood count (CBC) can reveal anemia from internal bleeding or infection. Urinalysis helps diagnose UTIs and kidney stones. Pregnancy tests are essential for women of childbearing age, as ectopic pregnancy can cause severe abdominal pain and requires emergency treatment.

Imaging studies like CT scans, ultrasounds, and X-rays help visualize internal organs and identify structural problems. Endoscopy or colonoscopy may be necessary to directly examine the digestive tract for ulcers, inflammation, or tumors.

Treatment Approaches and Management

Treatment for severe abdominal pain depends entirely on the underlying cause. While waiting for medical evaluation, avoid taking pain medications that could mask symptoms or worsen certain conditions. Don't eat or drink if you suspect appendicitis or bowel obstruction, as surgery may be necessary.

For digestive issues, treatment may include dietary modifications, probiotics, antacids, or prescription medications to reduce inflammation or regulate bowel function. Infections require appropriate antibiotics, while kidney stones may pass on their own with pain management and increased fluid intake, though larger stones might need surgical intervention.

Chronic conditions like IBS, IBD, or endometriosis often require long-term management strategies including medications, lifestyle changes, and regular monitoring. Working with healthcare providers to develop a comprehensive treatment plan helps minimize pain episodes and improve quality of life.

Prevention and Lifestyle Modifications

While not all causes of abdominal pain are preventable, many lifestyle factors can reduce your risk. Maintaining a healthy diet rich in fiber and low in processed foods supports digestive health. Staying hydrated helps prevent kidney stones and constipation. Regular exercise promotes healthy digestion and reduces stress, which can trigger or worsen abdominal pain.

Managing stress through relaxation techniques, adequate sleep, and mental health support can significantly impact digestive health. The gut-brain connection means psychological stress often manifests as physical abdominal symptoms. Avoiding trigger foods, eating smaller meals, and not lying down immediately after eating can prevent acid reflux and other digestive discomforts.

For those with chronic conditions, keeping a symptom diary helps identify patterns and triggers. Note what you eat, stress levels, medications, and pain characteristics. This information proves invaluable for healthcare providers in developing targeted treatment strategies.

If you have existing blood test results that might provide clues about your abdominal pain, you can get them analyzed for free using SiPhox Health's upload service. This AI-driven analysis can help identify potential metabolic or inflammatory patterns that might be contributing to your symptoms.

When to Seek Medical Care

Determining when abdominal pain requires medical attention can be challenging. Severe pain that interferes with daily activities, persists for more than a few days, or progressively worsens always warrants evaluation. Don't wait if you experience any emergency warning signs mentioned earlier.

For recurring abdominal pain, schedule an appointment with your primary care provider to discuss patterns and potential causes. They may recommend specialist referral to a gastroenterologist, urologist, or gynecologist depending on your symptoms. Early diagnosis and treatment often lead to better outcomes and prevent complications.

Keep detailed records of your symptoms, including timing, triggers, and what provides relief. This information helps healthcare providers make accurate diagnoses and develop effective treatment plans. Remember that severe abdominal pain is your body's signal that something needs attention, so don't ignore persistent or concerning symptoms.

The Path to Relief and Recovery

Living with severe abdominal pain can be physically and emotionally challenging, but understanding potential causes and seeking appropriate care leads to effective treatment. Whether your pain stems from a temporary condition or requires ongoing management, working with healthcare providers to identify the source and develop a treatment plan is essential for recovery.

Stay proactive about your health by maintaining regular check-ups, following prescribed treatments, and making lifestyle modifications that support digestive and overall wellness. With proper diagnosis and management, most causes of severe abdominal pain can be effectively treated, allowing you to return to normal activities and improved quality of life.

References

  1. Viniol, A., Keunecke, C., Biroga, T., et al. (2014). Studies of the symptom abdominal pain: a systematic review and meta-analysis. Family Practice, 31(5), 517-529.[Link][DOI]
  2. Cartwright, S. L., & Knudson, M. P. (2008). Evaluation of acute abdominal pain in adults. American Family Physician, 77(7), 971-978.[Link][PubMed]
  3. Penner, R. M., & Majumdar, S. R. (2023). Diagnostic approach to abdominal pain in adults. UpToDate.[Link]
  4. Macaluso, C. R., & McNamara, R. M. (2012). Evaluation and management of acute abdominal pain in the emergency department. International Journal of General Medicine, 5, 789-797.[PubMed][DOI]
  5. Ford, A. C., Lacy, B. E., & Talley, N. J. (2017). Irritable bowel syndrome. New England Journal of Medicine, 376(26), 2566-2578.[PubMed][DOI]
  6. Cervellin, G., Mora, R., Ticinesi, A., et al. (2016). Epidemiology and outcomes of acute abdominal pain in a large urban Emergency Department. Annals of Translational Medicine, 4(19), 362.[PubMed][DOI]

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Frequently Asked Questions

How can I test my inflammation markers at home?

You can test your inflammation markers at home with SiPhox Health's Core Health Program. This CLIA-certified program includes high-sensitivity CRP testing, providing lab-quality results from the comfort of your home.

What's the difference between acute and chronic abdominal pain?

Acute abdominal pain develops suddenly and may indicate conditions requiring immediate care like appendicitis or gallstones. Chronic pain persists for weeks or months and often relates to ongoing conditions like IBS, IBD, or endometriosis.

Can stress really cause severe abdominal pain?

Yes, stress significantly impacts digestive health through the gut-brain connection. Stress can trigger IBS flares, increase stomach acid production, alter gut bacteria, and cause muscle tension that manifests as abdominal pain.

Which blood tests help diagnose causes of abdominal pain?

Common blood tests include CBC for infection or bleeding, liver enzymes (ALT, AST) for liver/gallbladder issues, lipase/amylase for pancreatitis, CRP for inflammation, and kidney function tests (creatinine, BUN) for urinary problems.

When should I go to the emergency room for abdominal pain?

Seek emergency care for sudden severe pain, pain with fever over 101°F, persistent vomiting, blood in stool or vomit, abdominal rigidity, signs of shock, inability to pass gas or stool, or severe pain during pregnancy.

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Benjamin Bikman earned his Ph.D. in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore in metabolic disorders. Currently, his professional focus as a scientist and professor (Brigham Young University) is to better understand the role of elevated insulin and nutrient metabolism in regulating obesity, diabetes, and dementia.

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Director of Clinical Product Operations

Director of Clinical Product Operations at SiPhox Health with a background in medicine and a passion for health optimization. Experienced in leading software and clinical development teams, contributing to patents, launching health-related products, and turning diagnostics into actionable tools.

View Details
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Paul D. Thompson is Chief of Cardiology Emeritus of Hartford Hospital and Professor Emeritus at University of Connecticut Medical School. He has authored over 500 scientific articles on cardiovascular risk factors, the effects of exercise, and beyond. He received National Institutes of Health’s (NIH) Preventive Cardiology Academic Award, and has received NIH funding for multiple studies.

Dr. Thompson’s interests in exercise, general cardiology and sports cardiology originated from his own distance running: he qualified for the 1972 Olympic Marathon Trials as a 3rd year medical student and finished 16th in the 1976 Boston Marathon. Dr. Thompson publishes a blog 500 Rules of Cardiology where he shares lessons and anecdotes that he has learned over his extensive career as a physician, researcher and teacher.

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View Details
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Health Programs Lead, Health Innovation

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View Details
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Director of Clinical Product Operations

Director of Clinical Product Operations at SiPhox Health with a background in medicine and a passion for health optimization. Experienced in leading software and clinical development teams, contributing to patents, launching health-related products, and turning diagnostics into actionable tools.

View Details
Paul Thompson, MD

Paul Thompson, MD

Advisor

Paul D. Thompson is Chief of Cardiology Emeritus of Hartford Hospital and Professor Emeritus at University of Connecticut Medical School. He has authored over 500 scientific articles on cardiovascular risk factors, the effects of exercise, and beyond. He received National Institutes of Health’s (NIH) Preventive Cardiology Academic Award, and has received NIH funding for multiple studies.

Dr. Thompson’s interests in exercise, general cardiology and sports cardiology originated from his own distance running: he qualified for the 1972 Olympic Marathon Trials as a 3rd year medical student and finished 16th in the 1976 Boston Marathon. Dr. Thompson publishes a blog 500 Rules of Cardiology where he shares lessons and anecdotes that he has learned over his extensive career as a physician, researcher and teacher.

View Details
Robert Lufkin, MD

Robert Lufkin, MD

Advisor

Physician/medical school professor (UCLA and USC) and New York Times bestselling author empowering people to take back their metabolic health with lifestyle and other tools. A veteran of the Today Show, USA Today, and a regular contributor to FOX and other network news stations, his weekly video podcast reaches over 500,000 people. After reversing chronic disease and transforming his own life he is making it his mission to help others do the same.

His latest book, ‘Lies I Taught In Medical School’ is an instant New York Times bestseller and has re-framed how we think about metabolic health and longevity. In addition to being a practicing physician, he is author of over 200 peer reviewed scientific papers and 14 books that are available in fourteen languages.

View Details
Ben Bikman, PhD

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Advisor

Benjamin Bikman earned his Ph.D. in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore in metabolic disorders. Currently, his professional focus as a scientist and professor (Brigham Young University) is to better understand the role of elevated insulin and nutrient metabolism in regulating obesity, diabetes, and dementia.

In addition to his academic pursuits, Dr. Bikman is the author of Why We Get Sick and How Not To Get Sick.

View Details
Tash Milinkovic, MD

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Health Programs Lead, Heart & Metabolic

Dr. Natasha Milinkovic is part of the clinical product team at SiPhox Health, having graduated from the University of Bristol Medical School. Her medical career includes rotations across medical and surgical specialties, with specialized research in vascular surgery, focusing on recovery and post-operative pain outcomes. Dr. Milinkovic built her expertise in emergency medicine as a clinical fellow at a major trauma center before practicing at a central London teaching hospital throughout the pandemic.

She has contributed to global health initiatives, implementing surgical safety standards and protocols across rural Uganda. Dr. Milinkovic initially joined SiPhox Health to spearhead the health coaching initiative and has been a key contributor in the development and launch of the Heart and Metabolic program. She is passionate about addressing health disparities by building scalable healthcare solutions.

View Details
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Health Programs Lead, Health Innovation

Dr. Tsogbayar leverages her clinical expertise to develop innovative health solutions and evidence-based coaching. Dr. Tsogbayar previously practiced as a physician with a comprehensive training background, developing specialized expertise in cardiology and emergency medicine after gaining experience in primary care, allergy & immunology, internal medicine, and general surgery.

She earned her medical degree from Imperial College London, where she also completed her MSc in Human Molecular Genetics after obtaining a BSc in Biochemistry from Queen Mary University of London. Her academic research includes significant work in developmental cardiovascular genetics, with her thesis publication contributing to the understanding of genetic modifications on embryonic cardiovascular development.

View Details
Pavel Korecky, MD

Pavel Korecky, MD

Director of Clinical Product Operations

Director of Clinical Product Operations at SiPhox Health with a background in medicine and a passion for health optimization. Experienced in leading software and clinical development teams, contributing to patents, launching health-related products, and turning diagnostics into actionable tools.

View Details
Paul Thompson, MD

Paul Thompson, MD

Advisor

Paul D. Thompson is Chief of Cardiology Emeritus of Hartford Hospital and Professor Emeritus at University of Connecticut Medical School. He has authored over 500 scientific articles on cardiovascular risk factors, the effects of exercise, and beyond. He received National Institutes of Health’s (NIH) Preventive Cardiology Academic Award, and has received NIH funding for multiple studies.

Dr. Thompson’s interests in exercise, general cardiology and sports cardiology originated from his own distance running: he qualified for the 1972 Olympic Marathon Trials as a 3rd year medical student and finished 16th in the 1976 Boston Marathon. Dr. Thompson publishes a blog 500 Rules of Cardiology where he shares lessons and anecdotes that he has learned over his extensive career as a physician, researcher and teacher.

View Details
Robert Lufkin, MD

Robert Lufkin, MD

Advisor

Physician/medical school professor (UCLA and USC) and New York Times bestselling author empowering people to take back their metabolic health with lifestyle and other tools. A veteran of the Today Show, USA Today, and a regular contributor to FOX and other network news stations, his weekly video podcast reaches over 500,000 people. After reversing chronic disease and transforming his own life he is making it his mission to help others do the same.

His latest book, ‘Lies I Taught In Medical School’ is an instant New York Times bestseller and has re-framed how we think about metabolic health and longevity. In addition to being a practicing physician, he is author of over 200 peer reviewed scientific papers and 14 books that are available in fourteen languages.

View Details
Ben Bikman, PhD

Ben Bikman, PhD

Advisor

Benjamin Bikman earned his Ph.D. in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore in metabolic disorders. Currently, his professional focus as a scientist and professor (Brigham Young University) is to better understand the role of elevated insulin and nutrient metabolism in regulating obesity, diabetes, and dementia.

In addition to his academic pursuits, Dr. Bikman is the author of Why We Get Sick and How Not To Get Sick.

View Details
Tash Milinkovic, MD

Tash Milinkovic, MD

Health Programs Lead, Heart & Metabolic

Dr. Natasha Milinkovic is part of the clinical product team at SiPhox Health, having graduated from the University of Bristol Medical School. Her medical career includes rotations across medical and surgical specialties, with specialized research in vascular surgery, focusing on recovery and post-operative pain outcomes. Dr. Milinkovic built her expertise in emergency medicine as a clinical fellow at a major trauma center before practicing at a central London teaching hospital throughout the pandemic.

She has contributed to global health initiatives, implementing surgical safety standards and protocols across rural Uganda. Dr. Milinkovic initially joined SiPhox Health to spearhead the health coaching initiative and has been a key contributor in the development and launch of the Heart and Metabolic program. She is passionate about addressing health disparities by building scalable healthcare solutions.

View Details