How Tracking Biomarkers Can Increase Energy Levels

Feelings of exhaustion and constant fatigue are becoming more prevalent than ever in adults today, preventing than from engaging in daily activities. Several factors can contribute to low energy levels, including inadequate sleep, sedentary lifestyles, and underlying health issues. Certain biomarkers are linked to these factors, making it essential to track them to isolate the root of issues. Especially in the midst of COVID-19, low energy levels can indicate chronic fatigue syndrome (CFS). CFS greatly impedes productivity and quality of life while reducing life expectancy by over 20 years[1].


Low energy can be traced to a variety of causes

Several factors can contribute to low energy levels, including inadequate sleep, poor nutrition, a sedentary lifestyle, chronic stress, and underlying medical conditions such as anemia, thyroid disorders, or depression. Understanding the causes of low energy is crucial for identifying appropriate strategies to improve overall well-being and restore vitality.

Personalized reports

What is chronic fatigue syndrome?

Chronic Fatigue Syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a complex and debilitating condition characterized by persistent and unexplained fatigue that lasts for at least six months and is not improved by rest. CFS is often paired with disturbances to sleep, weakened cognitive function, and reduced physical ability. It is believed to be caused by genetic, immune, hormonal, and environmental factors, making it especially important to measure biomarkers that may influence this condition.

Connection to heart disease

Biomarkers shed light on causes of low energy

Due to the high variety of factors that influence energy levels and the fact that these many of causes do not manifest themselves visibly, it is difficult to pinpoint what is causing your fatigue. However, measuring biomarkers provides an accurate reason for low energy to inform further treatment or lifestyle changes, and can allow for preventative measures to stop energy levels from even dropping in the first place.

Which biomarkers are closely connected to low energy levels?


Proper insulin function maintains stable blood sugar for sustained energy. Imbalances manifest as insulin resistance, impairing glucose uptake and causing low energy. Hypoglycemia arises from excess insulin or insufficient glucose due to skipped meals, excessive insulin use, medical conditions, leading to fatigue and decreased energy levels.

Vitamin D

Vitamin D is crucial for overall health and energy levels. It supports cellular energy metabolism, muscle function, and immune function. Deficiency can lead to fatigue and increased vulnerability to illness. Adequate Vitamin D through sunlight, diet, or supplementation is essential for optimal energy and well-being.


Ferritin is the protein that stores iron. Iron deficiency, indicated by low ferritin levels, can cause fatigue. Iron is vital for oxygen transport and energy production in cells. Insufficient iron can hamper energy generation, resulting in tiredness and decreased energy. Addressing iron deficiency can alleviate fatigue and enhance energy levels.


Testosterone is essential for energy levels in both men and women. Adequate levels maintain energy, vitality, and motivation, supporting metabolic processes and muscle function. Low testosterone can lead to decreased energy, fatigue, reduced stamina, and lack of motivation, impacting quality of life. High testosterone can lead to irritability.

Here's the deal

Why choose SiPhox Health?

The lowest cost per biomarker testing, at-home sample collection,
interactive reports and actionable insights.

At-home testing

No more driving to clinics. No more waiting in lines. The sample collection kit lets you collect your sample using only a few drops of blood.

Extremely Affordable

Blood testing is expensive. But it shouldn't be. Meet SiPhox Health, the lowest cost per-biomarker test on the market (17 biomarkers for $95).

Measure progress

Users tell us that regular testing is key to reaching their goals. Whether you want to lose weight or have more energy—we have your back!

Actionable insights

Personalized insights sets you up for success. Paired with your favorite wearables, our system creates insights to improve each biomarker.


What the users are saying

Check out what our customers have to say about
the SiPhox Health biomarker test kit.

trustpilot reviews
trustpilot reviews
trustpilot reviews
trustpilot reviews
A few drops of blood
A few drops of blood

Is a few drops of blood really enough?

That's right! A few drops of blood is all we need to test 17 biomarkers. Sounds too good to be true? Far from it...

Our sample collection card, the ADX100[1], is an alternative collection method, similar to an SST tube. Red blood cells are separated without a centrifuge, enabling the laboratory to perform tests on dry blood.

Are results accurate? Yes! We process samples in a 3rd party CLIA-certified lab. The test results have been cross-validated against standard finger prick and venous draws.

Self sample-collection
Self sample-collection

Can I really collect my own sample?

Each kit contains a sample collection card, three adjustable lancets, band-aids, sterile gauze, an alcohol pad, and instructions.

Drawing your blood sounds scary at first. Especially if it's your first time doing it. We've taken the time to make the instructions as easy to follow as possible.

Not only that, every customer can schedule a live one-on-one session with our certified phlebotomist for FREE (a person trained in collecting blood samples).

Personalized reports
Personalized reports

Ok, my results are in. What now?

This is the best part! After processing your sample, we create a complete report for each of your 17 biomarkers.

You can then access your reports from your personal reports dashboard. Each report comes with an easy-to-understand graph and personalized insights you can use to improve each biomarker.

The dashboard lets you connect your favorite wearables to make your reports even more insightful. Improved sleep and activity scores are highly correlated with improved hormonal balance and lower inflammation in our user base.

Track and improve sleep, activity, and blood markers in a single dashboard

Include your wearable

Include Your Wearables
ACCU Check
Freestyle Libre

Frequently Asked Questions

If your question is not found below, feel free to email us your question at:

How do I get started?

You can sign up and place your initial order with us or you can submit your information and one of our team members will be in touch with you.

How do I place orders for my patients or customers?

As an enterprise customer, you will receive access to the SiPhox Health Portal where you can place orders, monitor lab results, customize notifications and view each of your patients’ data at any time.

Who can place orders for my patients or customers?

You can add users to the SiPhox Health Portal at any time and allow them to place orders for patients or customers. We recommend that your team familiarize themselves with the portal and we will provide training sessions and webinars as needed.

What is the minimum number of orders?

We have a minimum order size of 30 kits to become an enterprise partner. The initial order is priced at $120 per kit.

Are there any ongoing commitments?

No. There are no ongoing fees or long-term commitments. You simply pay as you go for the orders placed.

Do you offer volume discounts?

Yes! Volume discounts are offered when you reach 1,000 kits per month.

Do you offer customized panels?

Yes! Custom panels are offered when you reach 1,000 kits per month.

Do you have a SiPhox Health API?

Yes. We have a robust REST API that allows for creating orders, fetching customers, and fetching report data.

Do you sign BAAs with your partners?

Yes. We will sign a BAA with a Covered Entity.

How long does it take to implement the API?

It generally depends on your workflows and the complexity of the project. On average, our API can be implemented within a number of hours.

Do the kits get shipped to directly to the patient or to us?

It's completely up to you! We can ship kits directly to your patients or ship kits to you. You can even have us ship some kits directly to patients and others to you so you can have them on hand to distribute however you see fit.

What information is necessary to place an order for a patient or customer?

To place an order for a kit to go directly to a patient, we simply need their name, address and email.

Is the SiPhox Health blood test kit equivalent to standard labs?

Yes, we work with a CLIA/CAP accredited lab that performs extensive validation on each assay to meet federal CLIA requirements.

How are you able to offer the lowest cost per biomarker in the industry?

1. We bundle 17 biomarkers into a single sample collection, maximizing the data we collect from a single kit. Other companies like EverlyWell sell 2-4 markers per kit to maximize profits.

2. The SiPhox Health Unlimited Membership allows us to sell test kits at cost. The reason we are doing this is to drive demand and leverage that to drive our costs down.

3. SiPhox, the company behind SiPhox Health, develops blood testing hardware. Our goal is to eventually make it possible to test all these markers in the home instantly at a 10x lower cost.

Note that we do not compromise on the quality or accuracy of our tests in any way.

Why should I use a wearable with SiPhox Health?

SiPhox Health is not just another blood testing service delivering raw data to users. We are able to draw upon correlations between biomarkers and your wearable data. This allows you to optimize your lifestyle to improve your biomarkers.

What are the different types of subscriptions?

We currently offer the SiPhox Health Kits in the following models:

• The SiPhox Health Unlimited Membership: Pay as you go for unlimited at-home kits.

• Quarterly At-Home Tests: Receive four test kits per year.

• Yearly At-Home Test: Receive one test kit per year.

What wearable devices are compatible with SiPhox Health?

SiPhox Health currently has the ability to support over 300 devices across ten categories. The most common devices our users connect are Apple Watch, Oura, Fitbit, EightSleep, Whoop, and Freestyle Libre.

How do I view my test results?

When your SiPhox Health Report is ready for viewing, you will receive an email letting you know your user portal has been updated. You can access your report at any time by logging in and scrolling down to "Your Reports".

What makes SiPhox Health Reports unique?

Your SiPhox Health Reports are not just raw data. The team at SiPhox created a unique scoring system called the Axes of Wellness that spans different health and lifestyle categories such as Inflammation, Metabolic, and Cardiovascular Health. With this, we take the guesswork out of interpreting your results and empower you with actionable insights to improve your wellness.

If you would like to view your data in a traditional table format, you can do so by exporting the PDF within your report.

Can I modify, pause, or cancel my subscription?

Yes, you can easily do this inside your user portal any time after your initial purchase. There is no commitment whatsoever and you will keep access to your previous test data if you decide to cancel.

When is my card charged?

For Unlimited Members, your card is charged when you use a testing kit (ie complete registration).

For Quarterly and Yearly Members, your card is charged every time a testing kit is shipped to you. The frequency of shipping depends on your subscription type.

How can I refer a friend?

With our Refer & Earn program, you can share your enthusiasm for SiPhox Health, sending your friend a $20 discount off any plan and earning $50 off your next purchase. To set up your referral discount, log in to your SiPhox Health account and look for the orange button in the bottom left corner.

Can I give my kit away as a gift?

Yes, our system fully supports gifted kits. The recipient's results will be accessible to them through a separate, private account.

Why was I charged when I didn't place an order?

This is the charge for using the kit. Unlimited members are charged for test kits only after they register and use it. The membership fee does not include the cost of test kits. You are also shipped a replacement so you can always keep two kits on hand - but the replacement is only charged if and when you decide to use it.

I just signed up for Unlimited, what happens next?

When you sign up for Unlimited membership, you will receive 2 test kits and a starter kit (a box with extra tools for easier blood collection). You will only be charged $85 for each test kit after registering it and receiving the results. View a helpful graphic of the process here.

Is SiPhox Health HSA/FSA compatible?

If you have an HSA/FSA card you can simply use it for the purchase. If your card is not accepted, please contact support and we will send you an itemized receipt of all information necessary for reimbursement after purchase.

I’m having trouble collecting enough blood for the test, what can I do?

Please ship the sample back, and if the lab determines the quantity of blood is insufficient, they'll send you a free replacement kit. I recommend booking a free virtual phlebotomist session next time - it's a 15-minute Zoom call where a member of our team can guide you as you take your test. You can book it here.

I think I messed up my collection card. What do I do?

Don’t worry! This happens from time to time, especially on first attempts. Please take a photo of your ADX card and contact support at or simply use the chatbot on our webpage: We will assess whether you can still have a successful collection with your current kit, and if not, mail you a new kit free of charge.

What is the Hormone+ Panel?

The Hormone+ panel is available to all Unlimited members. It tests for 24 biomarkers - 17 from the standard panel and 7 additional gender-specific hormonal markers. If you've ordered multiple test kits, you will recognize the Hormone+ panel by an "H+" sticker and one additional blood collection card.

Men's Hormone+ add-on:

  1. Estradiol
  2. LH
  3. SHBG
  4. Prolactin
  5. FSH
  6. PSA
  7. Albumin
  8. Testosterone, free (calculated)

Women's Hormone+ add-on:

  1. LH
  2. Folate
  3. Vitamin B12
  4. Anti-Mullerian Hormone
  5. SHBG
  6. Prolactin
  7. DHEA-S